Pope Francis is due to visit Mozambique, Madagascar and Mauritius in September, the AFP news agency quotes the Vatican as saying.
Mozambique's President Filipe Nyusi invited the Pope on a visit to the Vatican last year.
In response, he joked that he would come "if I'm still alive".
Pope Francis visited Kenya, Uganda and the Central African Republic in 2015 and Egypt in 2017. He is due in Morocco at the end of the month.