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Manhyia South constituency is located in the Ashanti Region and is considered a stronghold for the New Patriotic Party (NPP).

Statistics compared from 1996 to 2016 shows the NPP has been maintaining a 'comfortable lead' in all the elections both presidential and parliamentary.

Parliamentary

Matthew Opoku Prempeh was the Member of Parliament in 2008 for the Manhyia constituency.

In 2012, he became the MP for the newly created Manhyia South when the number of constituencies was being increased from 230 to 275. Since it’s considered a safe seat for the NPP, he comfortably retained his seat in 2016 and he’s seeking reelection.